Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression thinking about harming or killing yourself, or planning or trying to do so extreme worry agitation panic attacks difficulty falling asleep or staying asleep aggressive behavior irritability acting without thinking severe restlessness or frenzied abnormal excitement.

You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You should know that your mental health may change in unexpected ways when you take desvenlafaxine or other antidepressants even if you are an adult over 24 years of age. Children younger than 18 years of age should not normally take desvenlafaxine, but in some cases, a doctor may decide that desvenlafaxine is the best medication to treat a child's condition. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as desvenlafaxine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so).

Desvenlafaxine succinate er